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发布于:2018-7-2 18:46:14  访问:221 次 回复:0 篇
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Why These Have Got To Be Among The Better Kept BKM120 Secrets On This Planet
We present the results from a prospective study of high-risk singleton pregnancies undergoing such a screening between 2002 and 2009 in Bulgaria. Bilateral UA Doppler analysis was performed between 18 and 24 w.g. Mean RI and PI indices were calculated. Presence of notching was also recorded. Logistic regression analysis was performed. 169 pregnant women were enrolled in the study. 37 patients developed PE and 11 of those delivered < 34 w.g. There was no difference in the mean maternal age, parity and gestational age between the groups at inclusion. The 90th centile RI had a better sensitivity for PE than the 95th centile with a FPR < 10%. The high mean PI raised the relative risk /RR/ for development of PE 4.8 times (71% sensitivity and 5.3% FPR, P = 0.034). The mean RI > 90th centile INK128 was associated with a significant increase of the RR for development of PE and early PE��3.8 and 8.5 times, respectively (95% CI 1.34�C10.9). The best predictor for development of PE and PE < 34 w.g. was the combination of RI > 90th centile and the presence of bilateral notching��65 times increased RR for development of early PE, with 81% sensitivity and 1.2% FPR (95% CI 6�C699). UA Doppler analysis is a non-invasive screening modality for Selleckchem Pexidartinib assessment of patients at risk for development of PE, in particular those requiring delivery < 34 w.g. RI and PI evaluation, combined with presence of notching, is the best predictor in identifying high-risk pregnancies. ""Antiphospholipid syndrome (APS) is frequently associated with uteroplacental circulation insufficiency leading to pregnancy complications, such as fetal loss, fetal growth restriction (IUGR), preeclampsia and thrombosis. The purpose of this study was to examine the relationship between Doppler flow parameters of the spiral artery (SA) and pregnancy outcome in women with pregnancies complicated by antiphospholipid syndrome. We examined 50 women with normal pregnancy and 28 women with pregnancy complicated by ASP. All pregnancies were singleton and were followed-up to the delivery. Spiral artery Doppler flow measurements (pulsatility index (PI) and resistance index (RI) were performed using BKM120 supplier transabdominal probe between 18 to 22 weeks of gestation. The ultrasound probe was positioned in vagina to visualize the hypoechoic parts of retroplacental area. Maternal spiral arteries were identified as having low-resistance, turbulent arterial flow. Obtained data were analyzed with paired Student‘s t-test. All patients with normal pregnancies delivered healthy fetuses at term. In the group of pregnant women with ASP��2 (7.1%) miscarriages were noted, 8 (28.6%) pregnancies were complicated by IUGR and 7 (25.0%) pregnancies were complicated by preeclampsia.
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